Polyethylene glycol (PEG) labeled liposomal drug delivery systems as a source for dynamic absolute MR thermometry
نویسندگان
چکیده
R. Deckers, S. M. Sprinkhuizen, B. J. Crielaard, J. H. Ippel, R. Boelens, T. Lammers, C. J. Bakker, and L. W. Bartels Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, Department of Pharmaceutics, Utrecht University, Utrecht, Netherlands, Department of NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands, Department of Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany
منابع مشابه
Fabrication of Clotrimazole microparticles using polyethylene glycol 6000 and beeswax
Backgrounds: Microparticles are one of drug delivery systems designed for sustained and controlled release of drugs for a long period of time. Clotrimazole is a broad-spectrum antifungal agent, which is generally used for treatment of Candida albicans and others fungal infections. Objectives: The present study aims to fabricate Clotrimazole microparticles using beeswax (lipophilic coating) an...
متن کاملDirect comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial?
Sterically stabilized liposome is characterized by a surface coating of polyethylene glycol (PEG) or other polymers that can reduce opsonization of the liposome by plasma proteins. It has a higher plasma area under the concentration-time curve (AUC), which is believed to correlate with better therapeutic efficacy. However, the presence of large molecules on the liposomal surface may reduce the ...
متن کاملImmunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid.
Polyethylene glycol (PEG) is used widely in the pharmaceutical industry to improve the pharmacokinetics and reduce the immunogenicity of therapeutic and diagnostic agents. The incorporation of lipid-conjugated PEG into liposomal drug delivery systems greatly enhances the circulation times of liposomes by providing a protective, steric barrier against interactions with plasma proteins and cells....
متن کاملEntrapped chemically synthesized gold nanoparticles combined with polyethylene glycol and chloroquine diphosphate as an improved antimalarial drug
Objective(s): Drug delivery is an engineering technology to control the release and delivery of therapeutic agents to target organs, tissues, and cells. Metallic nanoparticles, such as gold nanoparticles (AuNPs) have exceptional properties which enable efficient drug transport into different cell types with reduced side effects and cytotoxicity to other tissues.Materials and Methods: AuNPs were...
متن کاملChem. Pharm. Bull. 53(1) 27—31 (2005)
researched for use in drug toxicity reduction and/or drug targeting to desired target tissues. However, liposomes are rapidly removed from the circulation following their intravenous administration primarily by Kupffer cells in the liver and fixed macrophages in the spleen. Thus, it is important to develop modified liposomes that are able to avoid uptake by the reticuloendothelial system (RES) ...
متن کامل